Infection With Ascaris Eggs Relieves Symptoms Of Ulcerative Colitis – Part 2 of 3
Tissue captivated during active colitis showed a large number of CD4+ T-cells, which are immune cells that produce the inflammatory protein interleukin-17, the band found. However, tissue taken after worm therapy, when his colitis was in remission, contained lots of T-cells that make interleukin-22 (IL-22), a protein that promotes wound healing.
Further, after worm therapy, the man’s colon produced significantly more mucus who notable that a lack of mucus in the colon is linked with severe symptoms. “We think the worms increase or restore mucus movie in the colon. Basically, the gut is trying to expel the worms.
This increase in mucus may play a role in relieving the symptoms. This is not the usual clinical trial, but you take your opportunities for unique observation where you can,” said Dr Gerald W Dryden Jr, supervisor of the clinical research division of gastroenterology, hepatology and nutrition at the University of Louisville, in Kentucky.
Before this study, IL-22 had not been associated with salutary effect in IBD, said Dryden. “While it doesn’t determine cause-and-effect, the study does seem to demonstrate an important, previously unknown association between IL-22 and response to helminthic therapy”.
Causing abdominal pain, diarrhea and other symptoms, colitis affects about 700000 Americans, according to the Crohn’s and Colitis Foundation of America. Scientists don’t discern what causes the disease, but theorize that immune-system dysfunction plays a role.